This site was created for the sole purpose of sharing information, experiences and a list of animals, as submitted by breeders and owners, showing their status as Normal by Testing, Normal by Parentage (both sire and dam were tested or their sire's and dam's were tested), Carrier or Affected.
This site is for information only - the testing results belong to the owners of the animals at the time of submission. It is the responsibility of the buyer and seller to have the conversation and to share proof of test results. The data base is for general reference purposes - and the site owner bears no responsibility for the accuracy of the claims.
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G6-S is short for N-acetylglucosamine-6-sulfatase. It’s a naturally occurring enzyme that helps maintain connective tissues throughout a mammal’s body. When we refer to G6S as a concern with carriers and affected animals, is a mutation that stops the production of the enzyme before it’s completed, causing a substance called glycosaminoglycans to accumulate in the liver and brain. This creates the progressive specific neuron-generative disease. Symptoms of G6S include slowed growth, lack of muscle mass, blindness, deafness and eventually death caused by liver failure. Most don't live beyond a year.
G6S occurs only in Nubian goats and those with Nubian blood in their background, like Mini-Nubians or other mixes. In a human version, called Sanfilippo IIID, affected babies appear normal at birth but soon stop growing, develop neurological difficulties and then die. When the same defect was found in Nubian goats, researchers used Nubians as models for identification and possible treatment, and goat breeders benefited from their discoveries.
G6S is an autosomal recessive trait. it involves only one gene, it isn’t sex-linked (both males and females inherit equally) and two copies of the defective gene must be present for a kid to be affected. That means he inherits it from both parents.
There are now two (2) ways to test for this genetic deficiency - though blood and now hair follicles. Unfortunately, many Nubian goat breeders don’t know about it. Tested goats are given the designation Normal, Carrier or Affected. Once tested, they never have to be tested again.
Normal goats bred to other Normal goats always produce Normal babies, so their kids don’t need to be tested at all. If a Normal goat is bred to a Carrier, 50 percent of the offspring will be Normal and 50 percent are Carriers. Two mated Carriers produce 25 percent Normal, 50 percent Carrier and 25 percent Affected kids. The offspring of Carrier goats should always be tested. Affected adult goats are rarely bred because most are obviously ill before reaching breeding age.